But it remains an important and impressive finding that a decade or more is possible, showing that islet transplantation has quite some potential to succeed. Dr. Xu discovered that both RA and its analog RA-amide potently inhibit amylin aggregation and reduces aggregation-induced toxicity in vitro. Explore some of the latest innovations and discoveries and see how the ADA continues to advance science, leverage investments and retain scientists. That’s a big problem for our field and for the diabetes community.”. Purpose:As an emerging epidemic in the US and worldwide, obesity is associated with a constellation of metabolic disorders including insulin resistance, glucose intolerance, type 2 diabetes, hypertension and cardiovascular abnormalities. We do this by funding research towards the prevention, management or cure for diabetes. Approximately 40,000 new patients are diagnosed yearly. a large-scale clinical trial that investigated whether vitamin D supplementation helps prevent or delay type 2 diabetes in adults who are at high risk. This study brought up discussion about the January 2019 news that the British healthcare system NHS will provide CGMs to women with T1D during pregnancy, beginning in 2021. At the Forefront of Diabetes Research The U.S. government spends more than $1 billion a year on diabetes research. New research shows that eating too much gluten in the first 18 months of life may also be a trigger to developing T1D. For millions of children and adults living with diabetes today, a cure would mean: Recently published articles from Diabetes Research and Clinical Practice. In 2018 a follow up report on a total of 232 participants both treated and untreated with BCG, published in the journal Vaccines, showed positive results in lowering blood sugars in subjects with type 1 diabetes to almost normal levels while also reducing the amount of insulin needed about one-third after 5 to 8 years from the initial treatment with the BCG vaccine without any reports of severe hypoglycemia. That was one of many pregnancy-related sessions and research posters presented at ADA. The American Diabetes Association funds a productive research portfolio that offers significant progress and hope for improved outcomes for people with type 1 diabetes. A study found that despite all the fear of high blood sugars, higher blood pressure levels are just as dangerous for teens with T1D in developing heart disease. Type 2 diabetes is a hot area of research and a number of new treatments are currently being researched. Insulin maker Eli Lilly and Swiss pump company Ypsomed are creating a new automated system for people with diabetes. Why Is Emergency Glucose Packaging so Hard to Open? With this project, the researchers plan to introduce technology to all our newly diagnosed type 1 diabetic patients at diagnosis. What diabetes funding is available generally goes to established scientists. To make that vision a reality, we are laser focused on one goal: to discover a biological cure. Particularly in the case of chronic conditions such as diabetes, groundbreaking research can transform and save lives. Clinical Application of the Effects of Fat, Protein, and Glycemic Index on Postprandial Glucose Control If this project is successful, 50-60% of T1D patients who have specific high risk gene may benefit from this therapeutic modality. DiabetesMine reviews Tandem Diabetes exciting new Control-IQ system that partially automates insulin delivery. In this study, Dr. Wen will investigate how the clock genes regulate the functions of pancreatic islets and gut differently, with the ultimate goal to provide new knowledge to improve the effectiveness of existing therapy and to design more effective new therapy to treat or prevent type 1 diabetes. Increased consumption of omega-3 polyunsaturated fatty acids (PUFA) from cold water fish and fish oils have been associated with a decreased risk of diabetes and cognitive decline associated with diabetes. of NeurologyUniversity of Maryland School of MedicineBaltimore, MD. This discovery is the first evidence we’ve seen that clinical type 1 diabetes can be delayed with early preventive treatment,” said Dr. Lisa Spain at the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Canadian Journal Of Diabetes Diabetes Canada Professional Section members have full access to current … Type 1 diabetes develops when a person's immune system wipes out insulin-producing beta cells in the pancreas. At the Diabetes Research Institute Foundation, we have faced the pandemic with a view toward the future. Meanwhile, the ADA is making an effort to better connect with the patient community through its recent rebranding effort. In what’s dubbed the DiRECT (Diabetes Remission Clinical Trial) study, researchers also found that in early type 2, insulin-producing beta cells are not damaged and “irreversibly lost” as previously thought. Our research's impact. Current Research. She discussed the evidence from five clinical trials examining low-carb eating and a systematic review of health outcomes. But it turns out that another type of immature beta cell has been hiding in our pancreases all along, and scientists think it might be possible to use these 'virgin beta cells' to … Interestingly, one of the lead UK study authors, Dr. Roy Taylor, says this may indicate a new focus for type 2 diabetes management and messaging that the medical community should embrace: weight loss is a way to better handle the rising T2D epidemic globally. Diabetic ketoacidosis and hyperosmolar hyperglycemic state are medical emergencies because they can cause coma and death. Nearly 26 million Americans have the disease, including over 10% of the total adult population and over 25% ofthepopulationaged65yearsandolder. Purpose:Neuropathy eventually affects over 60% of patients with type 1 diabetes. ProfessorDirector Applied Metabolism & Physiology LabUniversity of VirginiaCharlottesville, VA. Purpose:Bariatric surgery is increasingly being used as a therapeutic option to combat rising rates in obesity and, in some cases, also treat diabetes and cardiovascular risk factors. This study will determine whether dietary VA status contributes to type 2 diabetes development in Zucker diabetic fatty rats, a model of type 2 diabetes due to over-nutrition. Please find 3174 such items on this topic. Diabetes Educ. Although these phenotypes are observed, these compounds have limited intestinal absorbance and are not observed in circulation. With research and awareness in mind, here are some new developments in both Type 1 and Type 2 diabetes. TIR is of course time spent within a healthy glucose range throughout days and weeks, when patients are not experiencing overly High or Low glucose levels. These studies are likely to provide novel therapeutic target for controlling blood sugar levels in type 2 diabetes. Purpose:Diabetic patients often develop non-healing foot ulcers that result in lower limb amputations. Researcher:Bin Xu, Ph.D.Assistant ProfessorPrincipal InvestigatorBiomanufacturing Research Institute and Technology Enterprise (BRITE)North Carolina Central UniversityDurham, NC. Many in the D-Community have been arguing for years that beyond A1C, the three-month average glucose measure that is currently gold standard, Time-in-Range (TIR) possibly matters more. As cases of the novel coronavirus began presenting and comorbidities like diabetes impacted patients at significantly higher rates, we knew that our work to find a cure was more important than ever. It certainly is, and when that research is in the field of medicine, the impact on humankind can be immense. These important cells are called B-cells. A research study to help improve treatment of type 2 diabetes, by learning how individuals respond to different blood sugar-lowering drugs. Almost 300 patients were enrolled, showing that a commercial weight loss plan followed by dedicated weight loss management allowed 36% of the participants to go into T2D remission and keep that up for two years. Much of the talk centered around information from a study published last year that looked at induction at 38 weeks versus 40 weeks and the impact on infant size and neonatal hypoglycemia. Trends Telemed E-Health. This effect may be related to the anti-inflammatory properties of omega-3 PUFA. The 2017 Millennium Award – Type 2 was awarded to Dr Seth Masters of The Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne. Researcher:Dongmin Liu, PhDProfessorVirginia Polytechnic Institute & State UniversityBlacksburg, VA. Purpose:Type 2 diabetes is a fastest-growing health problem in the US. of Neurology, Anatomy and NeurobiologyVice Chair for Research, Dept. Type 1 diabetes is an autoimmune disease that occurs when the T cells of the immune system kill the beta cells and insulin can no longer be made. Specifically, research… We foster young and upcoming diabetes researchers, and diversity in research across many areas of importance. Dr. Russell’s lab obtained an FDA IND for NR treatment in human type 2 diabetic neuropathy. Oh, the complexity of human relationships! Diabetes is caused when there is a loss or destruction of the cells that secrete insulin. DiabetesMine takes a good, hard look at diabetes care for minorities: is it good enough? Current Research on Telemonitoring In Patients with Diabetes Mellitus: A Short Pragmatic Narrative Review. Current Research into Cures for Type-1 Diabetes News and updates on potential cures for type-1 diabetes, that are in human (or clinical) trials. Researcher:Steven K. Malin, Ph.D., Asst. This wasn’t the only mention of fish at this year’s conference, btw. Learn More. Researcher:Laurie P. Shornick, PhD Associate Professor of BiologySaint Louis UniversitySt. Diabetes is a disorder of metabolism—the way the body uses digested food for growth and energy. Researcher:Meredith Hawkins, MDProfessor, Dept. The researchers hope that this will lead to an increased number of B-cells that function normally so that the blood sugar levels can be kept under control. They have shown that the metabolites 5-phenylvaleric acid, homovanillic acid and hippuric acid enhance beta cell proliferation, survival and insulin secretion. 2015 Dec;41(6):665-76. In this project Dr. Liu will investigate whether a combination treatment with hispidulin and sulforaphane is more effective in preventing T2D development by simultaneously improving insulin sensitivity and preserving functional beta-cell mass in T2D mice. One of the likely causes is that more women with T1D are using CGMs during pregnancy. Diabetes affects an estimated 34.2 million people in the United States and is the seventh leading cause of death. Purpose:Insulin plays an important role in maintaining normal blood glucose levels by activating a series of actions referred to as the insulin signaling pathway in insulin target tissues. New research from T1D Exchange showed a general decrease in A1C levels for pregnant women these days, compared to six years ago. Dr. Xu hypothesizes that this immunotherapy may be a universal disease-modifying intervention for both type-1 and type-2 diabetes-induced kidney failure. Current Research in Clinical Diabetes and Obesity is a peer-reviewed open access journal which publishes emerging concepts and disseminates the ongoing research in multidisciplinary fields of Diabetes and Obesity. Delaying Type 2 Diabetes and Reducing Complications. StartRight This study aims to achieve more accurate early classification of diabetes and identification of which patients will rapidly require insulin treatment. While Urbanski’s session was powerful, her concluding statement on the research was a bit lukewarm: “The evidence suggests that a very low-carbohydrate diet may have health benefits for adults with type 1 diabetes, but clinical trials of sufficient size and duration are needed for this and all eating patterns.”. 100% of your donation for a research project goes directly to the scientists. But the TIR concept is most certainly gaining ground, as witnessed by its appearance in so many scientific posters and talks at #ADA2019. Activation of cannabinoid receptors (CB2) has been shown to be protective in non-diseased models, but their potential protective role in the cerebral circulation during diabetes remains unknown. Through screening candidates for barrier formation the researchers identified sucrose octasulfate aluminum complex and further engineered it to rapidly form an effective transient physical coating in-situ within the duodenum. However, recent work suggests that not all individuals respond the same way. In this project, Dr. Ozbolat will bioprint pre-vascularized pancreatic islets made of mouse insulinoma cells and rat heart microvascular endothelial cells into a perfusion bed in order to create a perfusable platform for microcirculation of the engineered islets. So naturally, last week’s 79th annual event – held in an unseasonably hot downtown San Francisco – featured updates on loads of new studies from around the country and world, now ready to be presented to medical peers. Researcher:Kevin W. Huggins, Ph.D.Associate ProfessorAuburn UniversityAuburn, AL. The numerous official categories include: diabetes complications, education, exercise, nutrition, psychosocial, clinical therapeutics, healthcare delivery/economics, pregnancy, pediatrics, epidemiology, immunology, insulin action, obesity and more. They have synthesized a new PLGA-Microsphere system able to release three important drugs to prevent islet rejection over a very long period of time, characterized the physical properties of the microsphere system, and by doing this, have made headway to determine the optimal drug doses within the PLGA. Improved glycemic control is associated with amelioration of diabetic neuropathy but there is no treatment that prevents neuropathy developing or progressing. Contributing factors to generate different progression mechanisms in early and late-onset diabetes will be examined. Publications. The aim of this project is to determine the molecular mechanisms by which intestine derived cocoa epicatechin metabolites improve functional B-cell mass, and to use this to develop treatments for patients with diabetes.. Advances in stem cell transplantation may replace the need for insulin in type 1 diabetes and may lead to repair of damaged heart tissue following a heart attack. TriMaster. Trigger finger is a common health condition with diabetes. The reason for this finding is unclear but pre-operative health related to adipose tissue immune health and insulin resistance appear important. The poster hall alone displayed a whopping 2,000+ research posters. Sinai Hospital expressed concern about a growing gap between all these clinical studies and practical, clinical care being delivered to patients. “Our researchers were intrigued by the findings suggesting that blood pressure and glycemia are similarly important for cardiovascular risk prediction in this type 1 diabetes patient group,” said lead study author Dr. Jingchuan Guo. Nearly 200 couples filled out a survey on measures of relationship satisfaction and depressive symptoms, and then participated in an 8-min video-recorded discussion about T1D in their lives. Find out more . Purpose:Diabetes technology is changing and has quickly become an integral part of diabetes care and management. Dr. Tessem’s lab hypothesized that cocoa epicatechins may be metabolized by intestinal bacteria to absorbable compounds that can enhance beta cell function. The researchers also hope to facilitate the development of T cells that can suppress the remaining disease-causing T cells. Studies have shown that dysfunction of NKA is associated with diabetic kidney failure, indicating that NKA activity is essential to kidney function. She found that A1Cs improved by a half percentage point in those who took care of their pet fish, in association with managing type 1 diabetes. Normally, cerebral blood flow will match metabolic demand (neurovascular coupling). Researcher:Kai Y. XuAssociate Professor of SurgeryUniversity of Maryland School of MedicineBaltimore, MD. Researcher:Melissa Brown, Ph.D., RDAssistant ProfessorUniversity of St. JosephWest Hartford, CT. Purpose: Diabetes is one of the most serious diseases affecting public health in the U.S. today. The American Diabetes Association funds a productive research portfolio that offers significant progress and hope for improved outcomes for people with type 1 diabetes. In past years, the ADA handed out guides the size of phone books to all attendees that listed details on every poster and its authors. Surgical isolation of the proximal bowel following this surgery is thought to be a critical driver of the observed clinical benefits. With research and awareness in mind, here are some new developments in both Type 1 and Type 2 diabetes. It certainly is, and when that research is in the field of medicine, the impact on humankind can be immense. Researcher:William G. Mayhan, Ph.D.Professor and DeanUniversity of South Dakota-Sanford School of MedicineVermillion, SD. Over the last year, Dr. Sobel’s lab has made much progress to overcome major obstacles that have prevented this therapy. Current Research into Cures for Type-1 Diabetes News and updates on potential cures for type-1 diabetes, that are in human (or clinical) trials. 2019. We will test the ability of the humanized mAb1E7 to inhibit disease associated auto-reactive lymphocytes of T1D patients. Whether micronutrients such as Vitamin A (VA) play a role in type 2 diabetes development is still an open question. Medtronic Diabetes has a long history of insulin pump leadership and is developing a new generation of devices. All rights reserved. Diabetes affects an estimated 34.2 million people in the United States and is the seventh leading cause of death. DiabetesMine provides details on how to stay safe from coronavirus when you have diabetes. Knoxville, TN Researcher:Guoxun Chen, Ph.D.Associate Professor, Dept. Defects in this pathway result in insulin resistance which predisposes an individual to the development of type 2 diabetes. Diversity, Inclusion and Equality (In T1D Research) I think it is important that we all support the Black Lives Matter movement in whatever we do. Researcher:Li Zhang, MD, Ph.D., Assistant ProfessorBaylor College of MedicineHouston, TX. The researchers believe this scenario contributes to ischemic stroke during diabetes. Recent Diabetes Research and Clinical Practice Articles. Medindia provides you with the latest news and research breakthroughs on Diabetes. Investments in type 1 diabetes research The CDC estimates that nearly 1.6 million Americans have it, including about 187,000 children and adolescents. Researcher:Jeffrey M. Karp, Ph.D., Associate ProfessorThe Brigham and Women’s HospitalCambridge, MA. There are limitations, of course, and the study authors caution the D-Community to not go down the rabbit hole of describing this as a potential cure for T1D. Researcher:Douglas Sobel, MDProfessor of Pediatrics, Chief Pediatric EndocrinologyGeorgetown UniversityWashingotn, DC. The results show that VA status regulates obesity development and fuel metabolism in Zucker fatty rats. Latest Research on Diabetes. Medical Disclaimer - The content on this website is provided for general information only and should not be relied upon as a substitute for any professional medical advice or treatment. Diabetes and Diet Current Research. This leaves a gap in our understanding of the T1D etiology and its increasing incidence. Purpose:Patients with type 2 diabetes have inappropriately high blood sugar levels, which is predominately produced by the liver. Purpose:The rise of obese population in the U.S. indicates more people with type 2 diabetes in the future, which can be attributed to genetic and nutritional factors. However, this regulation is lost in people with type 2 diabetes. Researchers enrolled 76 participants ages 8-49 who were relatives of type 1 PWDs (people with diabetes) who showed at least two types of diabetes-related autoantibodies and abnormal glucose levels — indicating they may be on the pathway to developing T1D. Diabetes Canada is committed to innovation and breakthrough research that will End Diabetes. Diabetes can affect many parts of the body and is associated with serious complications, such as heart disease and stroke, blindness, kidney failure, and lower limb amputation. They hope that future studies will lead to curing people with diabetes. The proposed investigation will test the hypothesis and examine the efficacy of immunotherapy on both type-1 and type-2 diabetes induced kidney failure. Though diabetes has no known cure right now, you should be aware of the recent medical advances and discoveries as researchers work on finding a cure and improving treatments. A safe, orally bioavailable therapy is needed that can be taken chronically to prevent neuropathy developing in young adults. Actually, the risk doubles when BP levels are at or greater than 120/80 mmHg. Therefore, understanding the underlying mechanisms responsible for obesity-associated chronic inflammation and the consequences on myocardial dysfunction is significant. DiabetesMine looks at what's wrong with the way glucose products are packaged for diabetes emergencies. However, suppression of all the T cells would lead to serious side effects such as an increased susceptibility to infections and cancer. Research, including the Diabetes Prevention Program Outcome Study (DPPOS), that evaluates the success of diabetes interventions and strategies. The findings will apply to both type 1 and type 2 diabetes, will help to reduce the public health burden caused by diabetes, and most importantly, will hopefully improve the quality of life of those suffering with diabetes. But the results, published during the ADA conference, were unfortunately rather “meh.”, The researchers note: “We found that among people with prediabetes and sufficient vitamin D level, vitamin D supplementation at 4,000 units per day did not significantly reduce the risk of diabetes.”. However, very little vitamin D is found in food, and your body’s ability to make vitamin D from sunlight depends on many factors, including your exposure to the sun, where you live, the time of year, and the time of day. Particularly in the case of chronic conditions such as diabetes, groundbreaking research can transform and save lives. Dr. Russell’s lab will test if dietary nicotinamide ribosome (NR), which repletes NAD levels, prevents neuropathy in an animal model of type 1 diabetes. These studies will set the rationale for development of prevention strategies based on the mechanisms causing the disease. Journal of Current Research in Clinical Diabetes and Obesity is an international peer-reviewed open access journal committed to increasing awareness, encouraging research and promoting better treatment for people suffering from diabetes and obesity. The Diabetes UK Research team bring you the latest news and views on our funded research, as well as responses to media stories about diabetes research, while our guest bloggers take you behind the scenes of their own research. Using data from a landmark observational study, the Coronary Artery Risk Development in Young Adults, this study aims to identify possible differences in the predictors of developing pre-diabetes and type 2 diabetes between early and late onset type 2 diabetes groups. The principal investigator of this proposal has investigated the roles of VA in the regulation of sugar and fat metabolism since 2006. We’d like to share some of the topics that most caught our eye: One of the most-discussed studies presented at this year’s conference was from the ongoing nationwide study TrialNET, showing that in those who are at “high-risk” for type 1 diabetes (i.e. Together, these studies will determine whether it is possible to restore the brain’s regulation of blood sugar in type 2 diabetes. About Journal; Aims and Scope; Editorial Board; Ethical Principles; Guidelines; Editor-in-Chief; Author; Editor; Reviewer; Submission; Phronesis Policies; Publication Pricing; Submit Your Paper; Terms and Conditions; Articles in Press; Current Issue; Archives; Under Review; Phronesis Policies. On the 31 July 2017 the Diabetes Alliance for Research in England (DARE) Study closed to recruitment and will no longer be recruiting any new volunteers. However, its invasive and non-reversible nature has limited its application to small patient subgroups. Diabetes research is one key to the future for all people with diabetes. The Clinical Research in Type 2 Diabetes (T2D) program supports human studies across the lifespan aimed at understanding, preventing and treating T2D. Purpose:Type 2 diabetes is associated with neurodegeneration leading to cognitive deficits. Typically, patients will need to wait months due to paperwork, insurance, and logistical issues before they can utilize these technologies. They are called "monogenic" forms of diabetes and new research is opening the door to specific treatments for these patients. Current treatments for retinopathy only address the end-stages of the disease, when the eye is already significantly damaged. Purpose:The goal of this project is to investigate the novel functions of botanical compound rosmarinic acid (RA) and its analog RA-amide, in the prevention and treatment of diabetes and its complications. Research presented by the T1D Exchange showed that there’s an important need in the D-Community to screen for anxiety, depression and distress related to hypoglycemia experiences and that healthcare providers need to talk more with their patients about this issue. The number of adults diagnosed with diabetes in the United States has more than tripled over the past 20 years. Recent Diabetes Research and Clinical Practice Articles. Every $1 the ADA invests in diabetes research leads to $12.47 in additional research funding. In that “year in review” highlights session towards the end of the ADA conference, Dr. Daniel Drucker of Mt. At the end of the day, we’re reminded that the ADA Scientific Sessions is indeed a conference by and for medical professionals – something we patients need to keep in mind. Researcher: Sandra Lobo, Ph.D.Director, Biomedical Research InstituteWestern Connecticut Health NetworkDanbury, CT. Purpose:Type 2 diabetes is a metabolic disease and a growing global epidemic. The current research, the authors note in their study paper, was made possible thanks, in part, to financial support from the research charity Diabetes UK. To have higher fasting glucose levels, which could have implications for human current research on diabetes on ways to improve insulin in. The incidence of stroke is increased by diabetes Denise L. 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